When I was younger, I had brain surgery, and both my mom and I had our blood types confirmed by the hospital. She’s O, and I’m AB+. I’ve looked into rare cases like cis-AB, but that doesn’t seem to explain it. Could there be a medical or genetic reason for this? New user pass phrase: I genuinely don’t know the answer
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It’s simple: your father has AB+
They tried to tell you about it a long time ago, but just couldn’t find the right moment. Just be grateful that they gave you family when you needed one. The details aren’t important.
If she’s your biological mother, maybe she has chimerism? Do you know what her parents’ blood types are?
But also are you sure she’s your biological mother?
Swapped at birth, calling it now
Cis-AB does literally explain it. I’m not sure what you meant there.
Donor conceived?
* Adopted
* Accidentally swapped at the hospital
* Mother has chimerism – this is rare, but definitely not unheard of – and her ovaries are from a different DNA than her blood
* Donor eggs due to fertility issues
* Original blood typing lab results were wrong and you are not O-/AB+ at all
Basically, it is not genetically possible for type O to naturally have an AB+ child.
(edit: fix typo and add additional possibility from u/Sehtal )
Just have both of you retake the test. I have medical records saying I was O neg as a child, recent tests show O+. There’s always mix ups by tired lab technicians around the world.
There’s plenty of ways for this to happen.
Her phenotype could be O, but her genotype could be A or B.
She could have chimerism.
Cis-AB would also explain it
Or, you may not be generically related to your mother.
Time for a Myheritage dna test!
I saw a video few months ago that transferring bone marrow cause a change of blood type, but idk in what cases or if only some blood types are used. But girl that talked about i had it changed to O.
She is not your biological mother. Sorry.
Ya something is not adding up there. Theoretically it’s possible that either you or your mom have an ultra rare medical condition, but it’s most likely (99%)that it’s not your biological mother
I’m looking forward to this conclusion on /bestofredditupdates
Chimera
There can be more going on, but most likely, your mother is not your biological mother.
It can be that your mother is a chimera and her blood cell lineage is genetically distinct from her egg cells. It is possible that your mother is phenotypic O, but genotypic A and/or B, e.g. H-antigen.
Was your mother (or you) ever treated for leukemia? Did one of you ever get a bone marrow transfusion (as receipient)?
And,… what is your father’s blood type?
Is either a medical rarity or she is not your bio mum OR the hospital gave you the wrong results (I would recheck to update your file)
So a lot of people are talking about adoption, mix ups etc. But, maybe you’re a secret military experiment that was grown in a lab and you will be activated when the moment is right. I mean it’s not impossible. Have you considered asking your mum about it or maybe the military’s genetic programming prevents you discussing the issue with her!?
There are some medications and illnesses that can change your blood type. I am A+ but before every major surgery I’ve had they still type my blood. I always ask why and they give me the same answer.
Do an Ancestry DNA test.
Cis-AB would explain it. You dismiss it pretty casually, even though you do not report that they tested.
Do you have some other reasons (other test results, appearance, other clues) to suspect you’re adopted or born via IVF egg donor, and just don’t want to explicitly bring it?
https://academic.oup.com/labmed/article-abstract/37/1/37/2657444?redirectedFrom=PDF#google_vignette
Mom could have an unusual A subtype that didn’t react with the test method used for her type.
Few possibilities,
Edit 2: 8. Actually it could technically also be a spontaneous mutation, if I remember correctly there’s only a single base pair difference between the A and O alleles so while extraordinarily rare, an O could theoretically mutate into an A.
Ya know, my mom is O+, dad is B-, and I never considered it odd that I’m AB-. I know for a fact that mom is O+ and I’m at least a A/B/AB negative type, because we have record of my being born jaundiced due to abo and rh incompatibility. Maybe I’ll have to look into confirming my blood type
Maube your dad has AB+ blood type?
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Switched at birth it has happened. DNA test?
Your options are 1: one of you was typed wrong at the clinic. Happens more often than you might think. This is why the patient receiving the blood gets typed and screened twice before they get blood. 2: your mom is not your mom. We’re you an IVF baby by chance?
The most likely explanation is that one of your test results are wrong. If not the chances are that she’s not your biological mom, that is probably more likely than her being ABO (unless she’s Asian)
What’s your father’s blood type?
You father is ab +
Your father was AB. Your mother is O. You are AB. I’m not sure I understand why this is even a question. The negative/positive is irrelevant as it is independent of the parents. In addition blood type genetics is not as simple as we were led to believe in high school. This is still an over simplification but it contains good basic information. https://www.thetech.org/ask-a-geneticist/articles/2006/ask199/
I am O- and my kid is AB+ and we’ve both had DNA tests done for health/genetic reasons – no doubt my kid.
My mother is O and I’m AB+
It’s not super common, but look up Bombay phenotype. A person can be genetically A/B/AB but lack the H antigen that is the precursor to A and B antigens, which means they look like type O.
I suspect bad memory is the culprit. I gave blood two years ago, was told my blood type (B I think) but I’ve already moved to unsure. Just wasn’t important enough to write down or remember. Wouldn’t be shocked if I’m A or O. Hospital will type you before transfusion. Shrug.
My oldest’s blood type is A+, I’m O+. My younger two are O- and O+. Because my blood type is only half the puzzle. My oldest’s father is probably type A (never asked him, terrible situation), while my husband and the father of my younger two is O-. So, what’s the blood type of your other DNA contributor?
In addition to the far most likely suspects: prior lab error, switched at birth or adopted, chimerism/mosaicism …
If you or your mother has received a number blood transfusions during your lifetime, it can change your blood type by introducing new antibodies.
Or if you or your mother have even been a stem cell or bone marrow transplant recipient. In the same realm, leukemia can also change blood type.
If you have stuff like birth certificates to back you up, hospital mixed up your test results. I would get a type card kit on ebay. If you have access to a diabetic’s pin-in-a-pen type of pricker use that instead of the blade-in-a-box ones.
Your father is AB+. O is not the presence of a HLA, it is the absence of either, so you could have gotten both from your father. It’s Cis-AB like you mentioned.
r/genetics might be more suited to answer this, if you’re sure of the results
If dad is type B this is entirely possible
Either those blood tests were wrong or u got a wild ass story behind ur birth bec no way u get AB from an O mom, she literally don’t carry A or B to pass on. i’d fr get retested or ask some deep questions lol.
Ok, here’s a scenario that we used to think was exceedingly rare, but is looking more common the more we need to use DNA in the course of medical treatments. Your mom may be a chimera. Like, you know how identical twins start out as one embryo that splits in two early in development? The reverse is also possible. Two embryos can fuse into one resulting in one person with two genomes. Your mom may have been the result of two genetically distinct embryos (fraternal twins) that fused very early in development. When this happens, the cells from the two embryos tend to flock together and form individual systems rather than dispersing themselves uniformly throughout the body. They’re not even found in equal proportion. So your mom’s reproductive system may have had a different genome than some of the other systems in her body. If her erythrocytes (the cells destined to become red blood cells) are type O that’s what they’d find in the blood test, and because O- blood is highly unlikely to illicit an immune response, she could go her whole life without ever knowing unless something extraordinary happens, like the whole fam needs to be blood typed because someone’s having major surgery and they need a compatible donor on standby in case they need an emergency blood or tissue donor.
My brother and I both have different blood types to our mum – she’s A something, we’re both O something like our dad. It’s not common (and more dangerous if the baby is male), but it’s not unheard of. We both look like her/her side as well as our dad’s side, we’ve been tested and all that and we’re deffo hers. Sometimes it just happens.
You have a father…
Could be a donor IVF egg! My mom did that because her eggs didnt work. So me and my sister have my dads genes and not my moms
There was a case where the mom’s genes didn’t match her several kids’. The state took the kids away, despite doctors and everyone testifying that the kids were hers.
Turned out, she had absorbed a non-identical twin sister in-utero. The mom’s reproductive organs were from the absorbed sister so the kids were genetically not the mom’s at all. The mom was the aunt to her own kids!
Scientists were astounded that the reproductive parts were able to coexist with the mom perfectly.
Anywho, there are many ways that your situation could’ve come to pass with your mom having done nothing immoral, illegal, or wrong in any way.
Please, come back and let us know when you find out to reason(s).
Because blood types aren’t black and white. My dad was O+ mom is O-, I’m A-, sisters are a mix of A. Mt husband is O+, both of my daughters are O+.
You can buy blood typing kits cheap on Amazon. If that comes up with the same, get a 23andMe, or similar.
ockham’s razor: you’re adopted