Pros and cons of accepting a manuscript transfer?

Submitted to Nature Ecology & Evolution, desk reject with a suggestion to transfer to Communications Biology.

What are the pros and cons of this decision? Would I do better to pull it and try for PNAS? If I tried for PNAS and didn’t get it, I could submit to Communications Biology on my own, right? Does being transferred increase the likelihood of getting accepted? Is it just a question of how much of a headache I’m willing to give myself over this? All other things being the same, would a PNAS pub vs a Comm Bio pub make a difference on my CV for getting a post doc or other academic position?

I’m brand new to publishing and am very grateful for any thoughts or advice!